The histopathological pattern of primary IgA nephropathy in a Malaysian patient population.
نویسندگان
چکیده
In the 10-year period from October 1977 to July 1987, 149 cases of primary IgA nephropathy were histologically confirmed through renal biopsies in the Department of Pathology, University Hospital, Kuala Lumpur. The ages of these patients ranged from 5 to 72 years, with the majority in the 20-30 year age group. There was no sex preponderance. The ethnic distribution showed a significant predominance of Chinese with 107 (71.8%) Chinese, 24 (16.1%) Malays, 15 (10.1%) Indians and 3 others. A wide range of renal glomerular pathology was seen, the commonest being diffuse mesangioproliferative glomerulonephritis (59.1%). Focal proliferative glomerulonephritis (14.1%) followed by minimal change glomerulonephritis (10.7%) were next in order of frequency. Immunofluorescence studies consistently demonstrated heavy and predominant IgA deposition in the mesangium. Weak deposition of C3, IgG and IgM were also observed in various combinations.
منابع مشابه
Clinical, Histopathological and Immunofluorescent Findings of IgA Nephropathy
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متن کاملClinical, histopathological and immunofluorescent findings of IgA nephropathy.
BACKGROUND IgA nephropathy, a prevalent disease in Asia, is considered the main cause of end stage renal disease among primary glomerular disease. OBJECTIVE To determine the frequency of different clinical, histopathological and immunofluorescent characteristics of IgA nephropathy. METHODS Renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. ...
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عنوان ژورنال:
- The Malaysian journal of pathology
دوره 12 1 شماره
صفحات -
تاریخ انتشار 1990